My daughter had two bulldogs, both had allergies but one was especially bad. They took him to Tuffs University animal hospital in Boston to try to find exactly what the problem was. He looked like an abused dog with large patches of hair missing and very raw skin. Anyway after thousands of dollars in tests vets decided his skin was way to inflamed to do any more allergy testing so opted to put him on atopica for six months to calm down the skin so they could do further testing. My son in law didn't want to put him on the atopica because he heard bad things about it but agreed to do it for a short time. Bear in mind the dog had every test known to man done on him and NOTHING showed up except the allergy problem. Two months later my daughter took him to the vet (our vet) because he had diareah, the dog was in stage 5 cancer. So it was back to Boston again where they told her he was a good candidate for chemotherapy so they tried that, he had one treatment, stayed at the hospital for 4 days and was allowed to come home. He wasn't acting sick at all and was scheduled for another treatment the following wednesday. Wednesday came, she took him, vet tech came in and did blood work and said if all was ok she'd be back to get him for his treatment. She walked out of the room, the dog stood up, turned in a circle and dropped dead. Twice they revived him and the third time they asked if she wanted them to crack his chest, she was devestated and asked if it would save him and they said probably not so she said "let him go". Been a really rough time for them getting over his loss and we just want to warn people about atopica. Can't say thats what killed him but think about it a perfectly healthy dog goes in for tests put on this medication and eogjt days after being diaganost with cancer he's dead? Think about it, I would never never let my dogs have this drug. Of course the atopica company refuses all responsibility but they did admit it destroys the amune system and killed t cells which fight off cancer. Its actually the drug used on people so they don't reject organs after organ transplant. Best keep it for what it was originally made for and not give it to pets. This atopica thing is strictly my opinion, can't prove anything but you make up your own mind about it.